The Academy, which counts Richard Branson and David Bowie among its 550 members, has voted to compile a shortlist that recognises 70 categories, spanning websites, interactive advertising, online film and video and mobile.
Wieden & Kennedy London has been nominated under the Best Use of Animation or Motion Graphics category for its Music Almighty work created for Nokia.
De-construct has been nominated in the Art category for its design of artist Keith Tyson’s website.
Wieden & Kennedy is one of several groups to receive multiple nominations. It is in the running for eight, along with Crispin Porter and Bogusky and Hyperfactory, while R/GA is up for 14.
The BBC and The Guardian are up for eight and six nominations respectively.
A full list of nominees can be found at www.webbyawards.com/nominees.
The winners will be announced on 5 May.