Blake, who was knighted last year, made his name as a children’s book illustrator, and is particularly known for his work with Roald Dahl.
Since 2000, he has also found himself producing works for the walls of museums, stations and other public spaces.
His work for the NHS Nightingale project has seen his illustrations installed in public and private hospitals around the world.
In the talk, organised by the Association of Illustrators, Blake will describe some of these projects, both from the point of view of the challenges involved and from that of the feelings and reactions of the people who encounter them.
An Evening with Quentin Blake is about the Royal Festival Hall, Southbank Centre, London SE1 on 4 February. Tickets cost £20 and can be booked at www.southbankcentre.co.uk/whatson.