Signatories to the letter, which is published in the Herald, include Gerry McCusker, owner of Dog Digital, which has offices in Glasgow, London and Singapore, and Adrian Searle, co-founder of Glasgow-based Freight Design.
They are joined by others including Alan Beck, owner of Alan Beck Product Design, and Athole Fleming, managing director of Athole Design.
The letter says, ‘We are involved in business and entrepreneurship at different levels in Scotland and around the world. We believe independence is in the best interests of Scotland’s economy and its people.
‘An independent Scotland will recognise entrepreneurs small and large as the real wealth and job creators of the nation’s economic future. It will encourage a culture in which innovation, endeavour and enterprise are nurtured.
‘It will place power in the hands of Scotland’s people to channel the huge resources of our country in the interests of those who live and work here.’
Other signatories to the letter include Stagecoach chairman Brian Soutar and Ralph Topping, the former chief executive of William Hill.
The pro-independece letter follows an open letter published yeaterday, in which 130 business leaders stated the case against an independent Scotland.
Signatories including HSBC chairman Douglas Flint and Audrey Baxter, executive chairman of Baxters Foods, cited uncertainty around issues including currency, regulation and tax pension as being ‘bad for business’.
Earlier this month Design Week asked representatives from Scottish consultancies including Tayburn, Tangent Graphic and O Street what they thought an independent Scotland might mean for the design industry. You can read their responses in full here.