Simon Hassan, Hye-Yeon Park, Will Shannon and Jade Folawiyo have been selected for the programme.
The four were chosen through an open-call process and asked to respond to a brief which considers the idea of imperfection either in an object, environment or experience. The results will go on show from 24 August 2011-22 January 2012.
Royal College of Art graduate Hassan will create a number of objects made from leather that will develop and evolve throughout the exhibition.
Park is to develop her RCA graduation project Mr Clock, which functions as a conventional clock when someone stands in front of it and at other times displays nonsensical and abstract configurations.
RCA graduate Shannon, whose work focuses on creating travelling workshops, is working on the Autonomous Workplace no004: Mobile Chipboard Factory for the show, a travelling production line which creates new products from unwanted furniture.
Folawiyo, who studied at Central Saint Martins College of Art and Design, will explore ways of tarnishing and rusting metals.
The Designers in Residence programme, now in its fourth year, aims to help designers at early stages of their career to build on their practice and develop new work.